Antimycobacterial and cytotoxicity evaluation of the constituents of Monodora carolinae

Authors

  • Nyangi Magori Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O Box 35061, Dar es Salaam, Tanzania
  • Stephen S Nyandoro Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O Box 35061, Dar es Salaam, Tanzania
  • Joan JE Munissi Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O Box 35061, Dar es Salaam, Tanzania
  • Matthias Heydenreich Institut für Chemie, Universität Potsdam, P.O. Box 601553, D-14415 Potsdam, Germany

Keywords:

Monodora carolinae, Annonaceae, prenylindole, cannabisin B, (Z)-hexade-7-enoic acid, antimycobacterial, cytotoxicity

Abstract

Phytochemical investigation of the stem bark of the recently described species Monodora carolinae (Annonaceae) afforded prenylindole derivatives (E)-4-(1H-indol-6-yl)-but-3-en-2-one (1), 5-formylindole (2), fatty acid (Z)-hexade-7-enoic acid (3) and the lignanamide cannabisin B (4). The structures of the isolated compounds were established using NMR and MS analyses. The antimycobacterial activities of the extracts and isolated compounds were evaluated against Mycobacterium madagascariense (MM) and M. indicus pranii (MIP) using the two-fold microtitre dilution method. While the extracts exhibited minimum inhibitory concentration (MIC) ranging from 500 – 1000 µg/mL, the isolated compounds were 125 – 250 µg/mL, indicating very low activity. Cytotoxic effects were evaluated using brine shrimp larvae whereby the ethanolic extract of the root bark exhibited the lowest LC50 (< 3µg/mL). Isolation of prenylindole derivatives is of chemotaxonomic significance that affirms taxonomic placement of this plant species into the genus Monodora. This is the first time cannabisin B is reported from the genus Monodora

Monodora carolinae , Annonaceae; prenylindole, cannabisin B, (Z)-hexade-7-enoic acid; antimycobacterial, cytotoxicity.

 

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Published

2021-04-17

Issue

Vol. 39 No. 1 (2013)

Section

Articles

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