Modelling the Effects of Antiretroviral Therapy on Kidney Diseases Among HIV Infected Individuals in Tanzania

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Abstract

This study examined the role of highly active antiretroviral therapy (HAART) in the dynamicsof kidney diseases among HIV-infected individuals. A deterministic model was formulated forthe dynamics of kidney disease in HIV-infected people with HAART as treatment in themodel. Numerical simulations showed that though HAART reduces HIV progression to theAIDS stage, there is an increase in HIV-related kidney diseases. Also, the result obtained inthis study showed that reducing the effective contact rate of HIV and improving theeffectiveness of HAART by 99% in preventing the progression from HIV without symptomsgroup to HIV-related kidney diseases can decrease the prevalence of HIV-related kidneydiseases. Therefore, based on the findings obtained to reduce the population of HIV-relatedkidney diseases in the general population Pharmacists should focus on improving HAARTwhich will reduce the progression of kidney diseases from HIV.